On the same day that both the Nevada State Athletic Commission (NSAC) and the UFC banned therapeutic-use exemptions (TUE) for testosterone-replacement therapy (TRT), one of the treatment’s poster boys, Vitor Belfort, has been pulled from a scheduled middleweight title fight against champion Chris Weidman at UFC 173.

Replacing Belfort will be former UFC light heavyweight champion Lyoto Machida. The news was revealed on Fox Sports 1 by UFC President Dana White.

Belfort, also a former UFC light heavyweight champion, has been a lightning rod of controversy since it was revealed he was undergoing TRT. The Brazilian tested positive for steroid use in 2006 and was subsequently fined and suspended by the NSAC. Belfort has not competed in the US, nor Nevada, since 2011. However, the 36-year-old remained confident that he would receive a TUE for the title clash with Weidman on May 24.

The Brazilian Machida has picked up two straight wins since dropping to 185 pounds late last year. The karate practitioner scored a violent, first-round head kick knockout of Mark Munoz at UFC Fight Night 30 in October and most recently cruised past former Strikeforce title holder Gegard Mousasi at UFC Fight Night 36 in February.

For Weidman, the bout will mark the second defense of his middleweight title. The unbeaten New Yorker captured the belt with a second-round knockout of long-reigning champion Anderson Silva at UFC 162 and then retained it in the pair’s rematch in December at UFC 168.

UFC 173 takes place from the MGM Grand Garden Arena in Las Vegas and airs live on pay-per-view.